Physiologic and pharmacokinetic changes in pregnancy
نویسندگان
چکیده
منابع مشابه
Physiologic and pharmacokinetic changes in pregnancy
Physiologic changes in pregnancy induce profound alterations to the pharmacokinetic properties of many medications. These changes affect distribution, absorption, metabolism, and excretion of drugs, and thus may impact their pharmacodynamic properties during pregnancy. Pregnant women undergo several adaptations in many organ systems. Some adaptations are secondary to hormonal changes in pregnan...
متن کاملPhysiologic changes during normal pregnancy and delivery.
The major adaptations of the maternal cardiovascular system that progress throughout gestation may unmask previously unrecognized heart disease and result in significant morbidity and mortality. Most of these changes are almost fully reversed in the weeks and months after delivery. Hemodynamic changes during pregnancy include increased blood volume, cardiac output (CO), and maternal heart rate;...
متن کاملPhysiologic changes in pregnancy and their impact on critical care.
OBJECTIVES To describe the major pregnancy-induced physiologic changes that affect the care of patients who are critically ill. METHODS We reviewed relevant textbooks and articles pertaining to physiologic alterations produced by pregnancy. Those changes that have a bearing on patients admitted to an intensive care unit were abstracted, summarized, and organized by organ system. CONCLUSIONS...
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Cardiovascular system One of the major alterations to the cardiovascular system seen in the pregnant patient is that of blood volume. During pregnancy, an increase is seen in plasma volume (up to 50%), red blood cell volume (up to 20%) and total blood volume (up to 35%). Healthy women in a normal first pregnancy increase their plasma volume from a nonpregnant level by approximately 1250 ml. In ...
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The coexistent of pregnancy and liver disease represent a complex clinical situation, besides the liver complications that present in pregnancy with a previous health liver, like intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy or HELLP syndrome with bleeding disorders and viral hepatitis, the previous liver damage with portal hypertension associated represent a clear state...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2014
ISSN: 1663-9812
DOI: 10.3389/fphar.2014.00065